An in vitro anticoagulant effect of Fenugreek (Trigonella foenum-graecum) in blood samples of normal Sudanese individuals.
نویسندگان
چکیده
Haemostasis is the process of forming clots in the walls of damaged blood vessels to prevent abnormal bleeding and to maintain intravascular blood in a fluid state. Fenugreek is largely universal staple herb, popular throughout history and it has been consumed for treatment of different disorders. We aimed to study the possible anticoagulant effect of Fenugreek aqueous extract in vitro by using blood samples of normal individuals. In vitro anticoagulant effects of Fenugreek aqueous extract (5%) in different volumes (25, 50 and 75 μL) were examined in the blood samples of normal individuals by measuring prothrombin time (PT). The aqueous extract of Fenugreek was found to inhibit coagulation process in vitro and significantly prolonged prothrombin time in a dose-dependent manner. Fenugreek aqueous extract in different concentrations inhibits clot formation and increases prothrombin time. Subject to further studies on efficacy and safety, It can well be used, in the future, as a supplementary anticoagulant agent in cardiovascular diseases and to prevent hypercoagulable states.
منابع مشابه
Effect of Trigonella foenum graecum (Fenugreek) on blood glucose in normal and diabetic rats.
Trigonella foenum graecum (Fenugreek) was administered at 2 and 8 g/kg dose orally to normal and alloxan induced diabetic rats. It produced a significant fall (P < 0.05) in blood glucose both in the normal as well as diabetic rats and the hypoglycemic effect was dose related.
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Trigonella foenum-gracum L. (Fenugreek) (Leguminosae) is employed as an herbal medicine. Its seeds are known for their carminative, tonic and antidiabetic effects. In the present study, we investigated the hypoglycaemic activities of the hydroalcoholic, ethanolic and chloroformic extracts of the Trigonella foenum-gracum seeds in streptozotocin-diabetic rats using interperitoneall (i.p.) adminis...
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ورودعنوان ژورنال:
- Sudanese journal of paediatrics
دوره 13 2 شماره
صفحات -
تاریخ انتشار 2013